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In ARDS patients, macrophages secrete CXCL8 (IL-8) to activate a circulating neutrophil recruitment cascade via C-X-C chemokine receptor 1 (CXCR1) receptors

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HMOX1 upregulation promotes ferroptosis in diabetic atherosclerosis

Gene-level read counts were obtained using featureCounts (v1.5.0-p3), and expression levels were normalized as FPKM values

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We next assessed if alkyne-HNE can bind to NLRP3 by treating THP-1 macrophages with 3 M HNE or 10 M alkyne-HNE after inflammasome activation by nigericin